Composition

Each vial contain 4gm Ceftriaxone

Description

Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges, eyes, and inner ear. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. Ceftriaxone is a commonly used antimicrobial due to its good activity against multi-drug resistant Enterobacteriaceae, its relatively safe adverse effect profile, and its long half-life which allows for the convenience of daily or twice-daily dosing.

Chemical structure

Indications

Ceftriaxone is used for the treatment of the infections (respiratory, skin, soft tissue, UTI) caused by susceptible organisms. Organisms that are generally susceptible to ceftriaxone include S. pneumoniae, S. pyogenes (group A beta-hemolytic streptococci), coagulase-negative staphylococci, Some Enterobacter spp, H. influenzae, E. coli, Klebsiella spp, M. catarrhalis, B. burgdorferi, and some oral anaerobes.

  • Black quarter
  • Haemorrhagic septicaemia
  • Nephritis
  • Cystitis
  • Endometritis
  • Metritis
  • Pyometra
  • Mastitis
  • Actinobacillosis
  • Bronchopneumonia
  • Osteoarthritis

Pharmacodynamics

Ceftriaxone is a cephalosporin/cephamycin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. Ceftriaxone has in vitro activity against gram-positive aerobic, gram-negative aerobic, and anaerobic bacteria. The bactericidal activity of ceftriaxone results from the inhibition of cell wall synthesis and is mediated through ceftriaxone binding to penicillin-binding proteins (PBPs)

Mechanism of action

Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell-wall synthesis and cell division. Binding of ceftriaxone to these enzymes causes the enzyme to lose activity; therefore, the bacteria produce defective cell walls, causing cell death.

Contraindications

Contraindicated in Penicillin Hypersensitive animals

Presentation Pack of 4gm

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Rudrapur Plant
Village- Lalpur, Kichha- Rudrapur Road, Rudrapur, U.S. Nagar, Uttarakhand, India - 263148

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B36, EPIP, Industrial Area, Sikandra, Agra, Uttar Pradesh, India - 282007

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