Composition

Ceftriaxone Sodium 3 gm

Sulbactum 1.5 gm

Introduction

Ceftriaxone is a third-generation semi-synthetic bactericidal cephalosporin antibiotic, Ceftriaxone is a third-generation semi-synthetic bactericidal cephalosporin antibiotic, resistant to various types of bacterial resistant to various types of bacterial β-lactamases. It has excellent activity against gram-lactamases. It has excellent activity against gramnegative bacteria as well as a wide range of gram-positive and some anaerobic bacteria, negative bacteria as well as a wide range of gram-positive and some anaerobic bacteria, including enterobacteriaceae, including enterobacteriaceae, Streptococcus pneumoniae Streptococcus pneumoniae, , Haemophilus infl uenzae Haemophilus in fl uenzae, Pseudomonas aeruginosa Pseudomonas aeruginosa and other non-enterococcal streptococci.

About

Ceftriaxone is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic. Ceftriaxone sodium is (6R,7R)-7-[2-(2- Amino-4-thiazolyl)glyoxylamido]-8-oxo-3[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-astriazin-3-yl)thio]methyl]-5-thia-1azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 72 -(Z)- (O-methyloxime), disodium salt, sesquaterhydrate. The chemical formula of ceftriaxone sodium is C18H16N8Na2O7S33.5H2O. It has a calculated molecular weight of 661.59.
Ceftriaxone is a white to yellowish-orange crystalline powder which is readily soluble in water, sparingly soluble in methanol and very slightly soluble in ethanol. The pH of a 1% aqueous solution is approximately 6.7. The color of Ceftriaxone solutions ranges from light yellow to amber, depending on the length of storage, concentration and diluent used.
Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzymeproduced by bacteria that destroys the antibiotics. Sulbactam is an irreversible inhibitor of β-lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic.

In view of the above-described state of the art, the objects of the invention are to provide a long acting injectable antibiotic composition that combines the advantages of minimal repetitive administration, efficient drug utilization, and minimal handling. Accordingly, a Kit Resulting to liquid long acting injectable formulation has been developed for the sustained release of cuplosporin in animals, which includes the advantages of prolonged release of the Antibiotics, easy Administration and good stability. An object of the invention is to provide a Kit Resulting to liquid long acting injectable formulation for combating Bacterial infestations and conditions. This object is achieved by formulations which comprise: (a) a therapeutically effective amount of an Antibiotic; (b) a solvent or mixture of biologically acceptable solvents; and a biologically acceptable and biodegradable polyester polymer with Preservative

Mode of action

Ceftriaxone selectively and irreversibly inhibits bacterial cell wall synthesis by binding to transpeptidases, also called transamidases, which are penicillin-binding proteins (PBPs) that catalyze the cross-linking of the peptidoglycan polymers forming the bacterial cell wall.

Sulbactam is a β-lactamase inhibitor. This drugis given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics

Indications

  • Clinical And Sub Clinical Mastitis.
  • Respiratory Tract Infection.
  • Genito-Urinary Tract Infection.
  • Gastro-Intestinal Infection.
  • Bone And Joint Infection.
  • Surgical Prophylaxis.
  • Skin And Soft Tissue Infection.
  • To Prevent Secondary Bacterial Infection.

Contraindication

Patients with previous hypersensitivity reactions to penicillin and other beta lactam antibacterial agents may be at greater risk of hypersensitivity to ceftriaxone (see WARNINGS – Hypersensitivity).

Pregnancy and lactation

Reproductive studies have been performed in mice and rats at doses up to 20 times the usual dose and have no evidence of embryotoxicity, fetotoxicity or teratogenicity. This drug should be used during.

Presentation

Pack of 4.5 gm

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