Composition

Each ml contain 10mg of doramectin

Description

Doramectin is a antiparasitic drug. Doramectin is belongs to macrocyclic lactones

Mechanism of action

It is neurotoxic to parasites by potentiating glutamate-gated chloride ion channels in parasites. Paralysis and death of the parasite is caused by increased permeability to chloride ions and hyperpolarization of nerve cells. It also potentiate other chloride channels, including ones gated by GABA. Mammals ordinarily are not affected because they lack glutamate-gated chloride channels, and there is a lower affinity for other mammalian chloride channels. Because doramectin ordinarily do not penetrate the blood-brain barrier, GABA-gated channels in the CNS of mammals are not affected. Therefore it produces longer and more sustained plasma concentrations. It is effective against nematodes and arthropods, but has no effect on flukes or tapeworms.

Indications

In cattles: For treatment and control of gastrointestinal nematodes, lungworms, eyeworms, warbles, lice, mange mites and ticks.

Gastrointestinal Roundworms
(adults and fourth stage larvae)
  Ostertagia ostertagi (including inhibited larvae)
  O. lyrata
  Haemonchus placei
  Trichostrongylus axei
  T. colubriformis
  T. longispicularis*
  Cooperia oncophora
  C. pectinata
*
  C. punctata
  C. surnabada
 (syn. mcmasteri)
  Bunostomum phlebotomum*
  Strongyloides papillosus
*
  Oesophagostomum radiatum Trichuris
 spp.*
   Lungworms (adults and fourth stage larvae)
  Dictyocaulus viviparus
Eyeworms (adults)
  Thelazia spp.
Grubs (parasitic stages)
  Hypoderma bovis
  H. lineatum

Sucking Lice
  Haematopinus eurysternus
  Linognathus vituli
  Solenopotes capillatus

Mange Mites
  Psoroptes bovis
  Sarcoptes scabiei

Swine:

Gastrointestinal Roundworms
(adults and fourth stage larvae)
  Ascaris suum
  Oesophagostomum dentatum
  Oesophagostomum quadrispinulatum*
  Strongyloides ransomi
*
  Hyostrongylus rubidus
*
 Lungworms (adults)
  Metastrongylus spp.
Kidney Worms (adults)
  Stephanurus dentatus
Mange Mites (adults and immature stages)
  Sarcoptes scabiei var. suis
Sucking Lice (adults and immature stages)
  Haematopinus suis

Contraindication

Pregnancy safe drug

No adverse effect

Presentation 20ml                                                                                                                                                                                                                                      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Rudrapur Plant
Village- Lalpur, Kichha- Rudrapur Road, Rudrapur, U.S. Nagar, Uttarakhand, India - 263148

Agra Plant
B36, EPIP, Industrial Area, Sikandra, Agra, Uttar Pradesh, India - 282007

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