Each vial contains
Cefoperazone 3 gm
Sulbactum 1.5 gm
The sulbactam sodium and cefoperazone sodium combination consists of a beta-lactamase inhibitor plus a beta-lactam.
This sulbactam/cefoperazone combination is available as a dry powder for reconstitution in a 1:1 ratio and 1:2 ratio.
The antibacterial component of sulbactam/cefoperazone is cefoperazone, a third-generation cephalosporin, which acts against sensitive organisms during the stage of active multiplication by inhibiting the biosynthesis of cell wall mucopeptide. Sulbactam does not possess any useful antibacterial activity, except against Neisseriaceae and Acinetobacter. However, biochemical studies with cell-free bacterial synthesis have shown it to be an irreversible inhibitor of most important beta-lactamases produced by beta-lactam antibiotic-resistant organisms.
The potential for sulbactam preventing the destruction of penicillins and cephalosporins by resistant organisms was confirmed in whole-organism studies using resistant strains in which sulbactam exhibited marked synergy with penicillins and cephalosporins. As sulbactam also binds with some penicillin binding proteins, sensitive strains are also often rendered more susceptible to sulbactam/cefoperazone than to cefoperazone alone.
The combination of cefoperazone and sulbactam is active against all organisms sensitive to cefoperazone
- Haemophilus influenzae
- Bacteriodes species
- Staphylococcus species
- Acinetobacter caloacetincus
- Enterobacter aerogenes
- Escherichia coli
- Proteus mirabilis
- Klebsiella pneumoniae
- Morganella morganii
- Citrobacter freundii
- Enterobacter cloacae
- Citrobacter diversus
Approximately 84% of the sulbactam dose and 25% of the cefoperazone doseadministered as sulbactam/cefoperazone is excreted by the kidneys. Most of theremaining dose of cefoperazone is excreted in the bile. After sulbactam/cefoperazone administration, the mean half-life for sulbactam is about 1 hour while that forcefoperazone is 1.7 hours
Power S indicated for the treatment of the following infections when caused by susceptible organisms:
- Respiratory tract infections (upper and lower)
- Urinary tract infections (upper and lower)
- Peritonitis, cholecystitis, cholangitis, and other intra-abdominal infections
- Skin and soft tissue infections
- Bone and joint infections
- Pelvic inflammatory disease, endometritis, gonorrhoea, and other infections of the genital tract
Because of the broad spectrum of activity of sulbactam/cefoperazone, most infections can be treated adequately with this antibiotic combination alone. However, sulbactam/cefoperazone may also be used concomitantly with other antibiotics if such combinations are indicated. If an aminoglycoside is used, renal function should be monitored during the course of therapy.