Composition

Each uncoated bolus contains 5 gm Sulphadimidine

Description

Sulphadimidine is a short-acting antibacterial agent. It is grouped under synthetic antimicrobial agents that contain the sulphonamide group.

Chemical structure

Indications

Urinary tract infection

Prostatitis ( infection of the prostate gland )

Respiratory tract infection

It inhibit the growth or reproduction of bacteria but not killing the bacteria. It blocks the synthesis of bacterial dihydrofolic acid and therefore inhibits the growth of bacteria

Mechanism of action


It inhibit the enzymatic conversion of pteridine and p-aminobenzoic acid (PABA) to dihydropteroic acid by competing with PABA for binding to dihydrofolate synthetase, an intermediate of tetrahydrofolic acid (THF) synthesis.

Contraindications

Sulphadimidine should not be used in patients suffering from porphyria, a disorder with an excess chemical called porphyrin that affects nervous system and skin

It is not recommended in kidney failure patients because the drug is rapidly excreted in urine

Patients with G6PD (glucose 6 phosphate dehydrogenase) deficiency should not take sulphadimidine because of the occurrence of blood disorders such as anemia, agranulocytosis, hemolytic anemia and thrombocytopenia

It should not be used in patients allergic to the drug

Presentation

1*4

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