CEFSAFE INJECTION

40000 in stock

Description

Composition

Each vial contains Sterile Ceftiofur Sodium equivalent to anhydrous Ceftiofur 1 gm

Description

Ceftiofur sodium for Injection contains the sodium salt of ceftiofur which is a broad spectrum cephalosporin antibiotic active against Gram-positive and Gram-negative bacteria including β-lactamase-producing strains. Like other cephalosporins, ceftiofur is bactericidal in vitro as a result of inhibition of cell wall synthesis.

 

Ceftiofur sodium has demonstrated excellent in vitro and in vivo activity against Mannheimia haemolytica and Pasteurella multocida, two of the major pathogenic organisms associated with bovine respiratory disease (pneumonia, shipping fever). This drug has also demonstrated excellent in vitro and in vivo activity against Histophilus somni (Haemophilus somnus) and in vitro activity against Corynebacterium pyogenes, two other bacterial pathogens associated with bovine respiratory disease (BRD). Ceftiofur has demonstrated in vivo and in vitro activity against Fusobacterium necrophorum and Bacteroides melaninogenicus, two of the major pathogenic anaerobic bacteria associated with acute bovine interdigital necrobacillosis (foot rot, pododermatitis). Ceftiofur has excellent in vitro activity against Gram-negative pathogens such as Actinobacillus pleuropneumoniae, Salmonella choleraesuis, Pasteurella multocida and the Gram-positive pathogen Streptococcus suis, all of which singly or in combination can be associated with swine bacterial respiratory disease (swine bacterial pneumonia). Ceftiofur has also demonstrated excellent in vitro and in vivo activity against respiratory pathogens of horses. The drug was very active in vitro against Streptococcus zooepidemicus, S. equi, Streptococcus spp.and Pasteurella spp. isolated from patients with infections. Ceftiofur has demonstrated in vitro and in vivo activity against Mannheimia haemolytica, the major pathogenic bacterium associated with ovine respiratory disease (pneumonia). Ceftiofur has also demonstrated in vivo and in vitro activity against bacterial pathogens from dogs with urinary tract infections. Ceftiofur was more potent (in vitro) than other beta-lactam antibiotics against strains of Escherichia coli and Proteus mirabilis.

 

Mechanism of Action

The mechanism of action Ceftiofur sodium of the cephalosporins involves inhibiting the synthesis of bacterial cell wall [2]. In a cephalosporin molecule, the β-lactam moiety is essential for antibacterial activity, but it is also very vulnerable to degradation.

 

Properties – Bactericidal.

Indications

  • Genital Tract Infections (UTI)
  • Respiratory Tract Diseased (RTI), Pneumonia, HS)
  • Foot Rot.
  • Prolapse of Uterus.
  • Post Operative care

 

Contraindications

As with all drugs, the use of Ceftiofur sodium for Injection is contraindicated in animals previously found to be hypersensitive to the drug. In the event of a hypersensitivity reaction following the administration of this drug, immediate appropriate therapy should be instituted.

 

Warnings

Treated swine and lambs must not be slaughtered for use in food for at least 24 hours after the latest treatment with this drug. No meat withdrawal period or milk withholding time is required for cattle when the drug is used according to the label directions and dosage. This drug is not to be administered to horses that are to be slaughtered for use in food. Antimicrobial drugs, including penicillins and cephalosporins can cause allergic reactions in sensitized individuals. (To minimize the possibility of such a reaction, users of such antimicrobial products, including ceftiofur, are advised to avoid direct contact of the product with the skin and mucous membranes). To limit the development of antimicrobial resistance:

  • Ceftiofur sodium for Injectionshould not be used as a mass medication for cattle, swine or any other species. Ceftiofur sodium for Injection should only be used to treat individual animals as per the indications.
  • The choice of Ceftiofur sodium for Injectionas the most appropriate treatment should be confirmed by clinical experience supported where possible by pathogen culture and drug susceptibility testing.
  • The extra-label drug use of Ceftiofur sodium for Injectionis not recommended.

 

Presentation

Pack of 1 gm

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