Description
Composition
Each ml contains 100 mg Enrofloxacin
Description
Enrofloxacin is a quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid substituted by an oxo group at position 4, a fluoro group at position 6, a cyclopropyl group at position 1 and a 4-ethylpiperazin-1-yl group at position 7. It is a veterinary antibacterial agent used for the treatment of pets. It has a role as an antibacterial agent, an antineoplastic agent and an antimicrobial agent. It is a quinolinemonocarboxylic acid, a quinolone , an organofluorine compound, a N-alkylpiperazine, a N-arylpiperazine and a member of cyclopropanes.
Chemical structure
Indications
- Mastitis
- Respiratory tract infection
- Pneumonia
- Haemorrhagic septicemia
- Black quarter
- Pyometra
- Metritis
- Joint ill
- Urinary tract infection
- Brucellosis
- Wooden tongue
- Gastrointestinal infection
- Coli septicemia
- Bronchopneumonia
- Chronic respiratory disease
- Colibacillosis
- Infectious corhyza
- Pasteurellosis
- Salmonellosis
- Fowl typhoid
- Fowl cholera
Mechanism of action
Its mechanism of action involves inhibition of deoxyribonucleic acid (DNA) gyrase, thus inhibiting both DNA and ribonucleic acid (RNA) synthesis. Sensitive bacteria include Staphylococcus, Escherichia coli, Proteus, klebsiella, and Pasteurella. Pseudomonas is moderately susceptible but requires higher doses.
Contraindications
Young dogs below 8 months of age as it causes arthropathic effects. Not recommended in horses GI and CNS disturbances are seen
Seizure disorder animals
Do not give above 5mg/kg per day in cats cause blindness
Should not give undiluted or rapid IV in dogs
Young animals cause cartilage damage
In Birds IM formulation has an extremely alkaline pH and should not be given repeatedly; best to avoid IV use in birds
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