SAFEOXY 20% LA INJECTION

500.001,000.00

Out of stock

Description

Composition

Each ml contains 200 mg Oxytetracyclin

Description

A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions.

Chemical structure  

Indications

Oxytetracycline is indicated for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.

Pharmacodynamics

Oxytetracycline is known as a broad-spectrum antibiotic due to its activity against such a wide range of infections. It was the second of the tetracyclines to be discovered. Oxytetracycline, like other tetracyclines, is used to treat many infections common and rare.

Mechanism of action

Oxytetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.

Contraindications

Hypersensitivity, retard fetal skeletal development, should not be used in 2nd  half of pregnancy, causes renal failure, hepatotoxicity

Rapid IV injection of Proppylene glycol containing products can cause intravascular hemolysis and cardiodepressant effects

Should not give oral tetracyclin to cat, can cause fever, hair loss, colic

The concentrated injectable depot formulation used for cattle and sheep should never be given to small animals

Rapid IV can cause cardiac arrhythmias and transient collapse due to chelation of intravascular Calcium ions

Adverse reaction

Include vomiting, diarrhoea, depression, hepatotoxicity( rare), fever, hypotension ( following IV administration)

Drug interaction

The bacterial action of penicilins may be inhibited by oxytetracycline, autacods containing divalent or trivalent cations ( Mg2+,Ca2+, Al3+ ) food or milk bind to tetracycline reducing its absorption.

Additional information

Presentation

30 ML, 100 ML

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