Safeoxy 5% injection
Each ml contains 50mg Oxytetracyclin
A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions.
Oxytetracycline is indicated for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.
Oxytetracycline is known as a broad-spectrum antibiotic due to its activity against such a wide range of infections. It was the second of the tetracyclines to be discovered. Oxytetracycline, like other tetracyclines, is used to treat many infections common and rare.
Mechanism of action
Oxytetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.
Hypersensitivity, retard fetal skeletal development, should not be used in 2nd half of pregnancy, causes renal failure, hepatotoxicity
Rapid IV injection of Proppylene glycol containing products can cause intravascular hemolysis and cardiodepressant effects
Should not give oral tetracyclin to cat, can cause fever, hair loss, colic
The concentrated injectable depot formulation used for cattle and sheep should never be given to small animals
Rapid IV can cause cardiac arrhythmias and transient collapse due to chelation of intravascular Calcium ions
Include vomiting, diarrhoea, depression, hepatotoxicity( rare), fever, hypotension ( following IV administration)
The bacterial action of penicilins may be inhibited by oxytetracycline, autacods containing divalent or trivalent cations ( Mg2+,Ca2+, Al3+ ) food or milk bind to tetracycline reducing its absorption.
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