49994 in stock



Albasafe contains 1.5gm of Albendazole


Albendazole is mainly used in cattle and sheep, but has found some use in cats and dogs as well; it is also used in ratite birds for flagellate parasites and tapeworms. It is also used off-label to treat endoparasites in goats and pigs.

Chemical structure


It is effective against gastrointestinal roundworms and lungworms of livestock, including adults and L4-larvae of the most important species (e.g. of the genus Bunostomum, Haemonchus,  Ostertagia-Teladorsaqia, Trichostrongylus, Coopreia, Nematodirus, Chabertia,Oesophagostomum, Trichuris, Dictyocaulus, etc.) as well as arrested larvae of several species. It is also effective against most livestock tapeworms  (e.g. Moniezia, Taenia) and against adult liver flukes  (Fasciola hepatica and Fascioloides magna ), but not against immature stages. As other benzimidazoles albendazole has no efficacy whatsoever against external parasites (ticks, flies, lice, mites etc).

In horses it controls the major parasitic roundworms such as Large Strongyles (Cyathostomins), Small Strongyles (Strongylus spp), Parascaris equorum, etc. as well as tapeworms (e.g. Anaplocephala spp).

It is also effective against the major parasitic roundworms (e.g. Ancylostoma, Toxocara, Trichuris, Uncinaria) and tapeworms (e.g. Echinococcus, Dipylidium, Taenia, etc.) of dogs and cats, as well as against giardiasis (beaver fever), a parasitic infection caused by Giardia spp, a protozoan parasite of animals and humans.


Albendazole is a broad-spectrum anthelmintic. The principal mode of action for albendazole is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules.

Mechanism of action

Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by diminishing its energy production, ultimately leading to immobilization and death of the parasite. It works by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. As cytoplasmic microtubules are critical in promoting glucose uptake in larval and adult stages of the susceptible parasites, the glycogen stores of the parasites are depleted. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth.


Albendazole undergoes very fast 1st-pass metabolism in all species i.e Hepatic metabolism. Rapidly converted in the liver to the primary metabolite, albendazole sulfoxide, which is further metabolized to albendazole sulfone and other primary oxidative metabolites.  In ruminants, however, 60–70% of the metabolites are excreted in the urine.


Avoid administration albendazole during first trimester of pregnancy, as it may be embro toxic and teratogenic


1*4 bolus

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