Description
Composition
Each ml contain 10mg of doramectin
Description
Doramectin is a antiparasitic drug. Doramectin is belongs to macrocyclic lactones
Mechanism of action
It is neurotoxic to parasites by potentiating glutamate-gated chloride ion channels in parasites. Paralysis and death of the parasite is caused by increased permeability to chloride ions and hyperpolarization of nerve cells. It also potentiate other chloride channels, including ones gated by GABA. Mammals ordinarily are not affected because they lack glutamate-gated chloride channels, and there is a lower affinity for other mammalian chloride channels. Because doramectin ordinarily do not penetrate the blood-brain barrier, GABA-gated channels in the CNS of mammals are not affected. Therefore it produces longer and more sustained plasma concentrations. It is effective against nematodes and arthropods, but has no effect on flukes or tapeworms.
Indications
In cattles: For treatment and control of gastrointestinal nematodes, lungworms, eyeworms, warbles, lice, mange mites and ticks.
| Gastrointestinal Roundworms (adults and fourth stage larvae) Ostertagia ostertagi (including inhibited larvae) O. lyrata Haemonchus placei Trichostrongylus axei T. colubriformis T. longispicularis* Cooperia oncophora C. pectinata* C. punctata C. surnabada (syn. mcmasteri) Bunostomum phlebotomum* Strongyloides papillosus* Oesophagostomum radiatum Trichuris spp.* |
Lungworms (adults and fourth stage larvae) |
Swine:
| Gastrointestinal Roundworms (adults and fourth stage larvae) Ascaris suum Oesophagostomum dentatum Oesophagostomum quadrispinulatum* Strongyloides ransomi* Hyostrongylus rubidus* |
Lungworms (adults) Metastrongylus spp. Kidney Worms (adults) Stephanurus dentatus Mange Mites (adults and immature stages) Sarcoptes scabiei var. suis Sucking Lice (adults and immature stages) Haematopinus suis |
Contraindication
Pregnancy safe drug
No adverse effect
Presentation
20 ml
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