Each ml contains 1mg Propoxur
Propoxur is an antiparasitic active ingredient used in veterinary medicine. It is used in dogs and cats against external parasites (lice, fleas etc).
Efficacy against parasite
Type of action: Broad-spectrum, contact, non-systemic insecticide.
Main veterinary parasites controlled: flies, lice, fleas, mosquitoes etc.
It is an parasiticide and its active ingredient used in pets and livestock against external parasites like lice, fleas, ticks, mites, flies, maggots etc
It is not effective against internal parasites
Use in livestock in very scarce and mainly it is used in dogs and cats. Not used in horses. Efficacy against a specific parasite depends on the delivery form and on the dose administered.
Mechanism of action
Propoxur acts on the nervous system of the parasites (but also of mammals, birds, fish and many organisms!) as inhibitor of acetylcholinesterase (also known as AchE), an enzyme that hydrolyzes acetylcholine (Ach). Ach is a molecule involved in the transmission of nervous signals from nerves to muscles and between neurons in the brain.
AchE’s role is to terminate the transmission of nervous signals. By inhibiting the activity of AchE, carbamates prevent the termination of those nervous signals, i.e. the neurons remain in constant activity and excitation, massively disturbing the normal movements of the parasites. The bottom line for the parasites is that they are paralyzed and die more or less quickly.